Weaponizing the Immune System

Dr. Goldstein’s NIH-funded research at Albert Einstein College of Medicine centers on developing agents to amplify the capacity of the immune system to control HIV infection.

In seeking to “weaponize” the immune system to cure HIV, the lab uses molecular, cellular, and biochemical approaches, including CAR-T cells and the novel treatment strategy developed by Dr. Almo at Einstein for selective T cell amplification called synTac (synthetic T-cell activation).

SynTac: A Novel Immunomodulatory Platform

SynTac: A Novel Immunomodulatory Platform
Generating CAR-T cells to Target HIV or Cancer

Generating CAR-T cells to Target HIV or Cancer
Investigating the Blood Brain Barrier in HIV+ Drug Users

Investigating the Blood Brain Barrier in HIV+ Drug Users

Lab News

  • Celebrating Erin

    August 2024

  • Congratulations Erin!

    Erin and Will at their beautiful wedding in Colorado!

    August 2024

  • Erin attends the American Society of Gene & Cell Therapy conference!

    Erin gave a poster presentation titled, “Generation of CD19 and HIV-Specific Tscm CAR-T Cells by Novel Cytokine-Based Scaffolds” at the ASGCT conference in Baltimore.

    May 8, 2024

  • Chris, April, and Erin present at SITC!

    November 3, 2023

  • Chris Wins 1st Place!

    Congratulations to Chris for winning 1st place in the Barry R. Bloom Speaker Award for best Work-in-Progress Seminar Series Presentation for the 2022-2023 academic year!

  • Goldstein Lab Attends the ERC-CFAR - REACH Symposium at Rockefeller University

    NYC Wide Research Symposium: Pathways to an HIV Cure on September 7, 2023

  • Erin is awarded the T32 Training Grant

    07/14/23

  • Sara and Erin pass the qualifying exams!

    05/18/23

  • Goldstein lab attend CROI 2023!

    02/19/23

    April, Chris, and Hang are awarded the Young Investigator Scholarship awards to attend the 30th Conference on Retroviruses and Opportunistic Infections, where they met Dr. Fauci!

  • New Paper in JCI Insight!

    In vivo killing of primary HIV-infected cells by peripheral-injected early memory–enriched anti-HIV duoCAR T cells

    JCI Insight. 2022;7(21):e161698. https://doi.org/10.1172/jci.insight.161698.

  • Sara Declares in the Lab!

    06/13/2022

  • Derek Starts his Rotation!

    06/08/2022

  • Hang presents at WIP!

    06/10/2022

  • Erin Declares in the Lab!

    06/03/2022

  • Chris presents at WIP!

    06/03/2022

  • April Passes her Qualifying Exam!

    05/18/2022

  • Our new R01 will be funded for the full five years!

    05/17/2022

  • April presents at WIP!

    05/13/2022

  • Mo presents at WIP!

    04/01/2022