Selected Publications
Kim Anthony-Gonda, Alex Ray, Hang Su, Yuge Wang, Ying Xiong, Danica Lee, Ariele Block, Vanessa Chilunda, Jessica Weiselberg, Lily Zemelko, Yen Y. Wang, Sarah Kleinsorge-Block, Jane S. Reese, Marcos de Lima, Christina Ochsenbauer, John C. Kappes, Dimiter S. Dimitrov, Rimas Orentas, Steven G. Deeks, Rachel L. Rutishauser, Joan W. Berman, Harris Goldstein, and Boro Dropulić. In vivo killing of primary HIV-infected cells by peripheral-injected early memory–enriched anti-HIV duoCAR T cells JCI Insight. 2022;7(21):e161698. https://doi.org/10.1172/jci.insight.161698.
Li M, Garforth SJ, O'Connor KE, Su H, Lee DM, Celikgil A, Chaparro RJ, Seidel RD, Jones RB, Arav-Boger R, Almo SC, Goldstein H. T cell receptor-targeted immunotherapeutics drive selective in vivo HIV- and CMV-specific T cell expansion in humanized mice. J Clin Invest. 2021 Dec 1;131(23):e141051. doi: 10.1172/JCI141051. PMID: 34673568; PMCID: PMC8631598.
Powell AB, Ren Y, Korom M, Saunders D, Hanley PJ, Goldstein H, Nixon DF, Bollard CM, Lynch RM, Jones RB, Cruz CRY. Engineered Antigen-Specific T Cells Secreting Broadly Neutralizing Antibodies: Combining Innate and Adaptive Immune Response against HIV. Mol Ther Methods Clin Dev. 2020 Aug 21;19:78-88. doi: 10.1016/j.omtm.2020.08.015. PMID: 33005704; PMCID: PMC7508916.
Wu Y, Xue J, Wang C, Li W, Wang L, Chen W, Prabakaran P, Kong D, Jin Y, Hu D, Wang Y, Lei C, Yu D, Tu C, Bardhi A, Sidorov I, Ma L, Goldstein H, Qin C, Lu L, Jiang S, Dimitrov DS, Ying T. Rapid Elimination of Broadly Neutralizing Antibodies Correlates with Treatment Failure in the Acute Phase of Simian-Human Immunodeficiency Virus Infection. J Virol. 2019 Sep 30;93(20):e01077-19. doi: 10.1128/JVI.01077-19. PMID: 31375583; PMCID: PMC6798097.
Flerin NC, Bardhi A, Zheng JH, Korom M, Folkvord J, Kovacs C, Benko E, Truong R, Mota T, Connick E, Jones RB, Lynch RM, Goldstein H. Establishment of a Novel Humanized Mouse Model To Investigate In Vivo Activation and Depletion of Patient-Derived HIV Latent Reservoirs. J Virol. 2019 Mar 5;93(6):e02051-18. doi: 10.1128/JVI.02051-18. PMID: 30626677; PMCID: PMC6401459.
Anthony-Gonda K, Bardhi A, Ray A, Flerin N, Li M, Chen W, Ochsenbauer C, Kappes JC, Krueger W, Worden A, Schneider D, Zhu Z, Orentas R, Dimitrov D, Goldstein H, Dropulić B. Multi-specific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells. Science Translational Med. 2019:11:pii: eaav5685. doi: 10.1126/scitranslmed.aav5685. PubMed PMID: 31391322.
Bardhi A, Wu Y, Chen W, Zhu Z, Zheng JH, Wong H, Jeng E, Jones J, Ochsenbauer C, Kappes JC, Dimitrov DS, Ying T, Goldstein H. Potent in vivo NK cell-mediated elimination of HIV-1-Infected cells mobilized by a gp120-bispecific and hexavalent broadly neutralizing fusion protein. J. Virology 2017:91:pii: 00937-17. doi: 10.1128/JVI.00937-17. PubMed PMID: 28794022. PMCID: PMC5625480.
Flerin NC, Chen H, Glover TD, Lamothe PA, Zheng JH, Fang JW, Ndhlovu ZM, Newell EW, Davis MM, Walker BD, Goldstein H. T-Cell Receptor (TCR) Clonotype-Specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T-Cell Clones Is Not Mediated by TCR Alone. J. Virology 2017;91:e02412-16. doi: 10.1128/JVI.02412-16.
Thomas T, Seay K, Zheng JH, Zhang C, Ochsenbauer C, Kappes JC, Goldstein H. High-Throughput Humanized Mouse Models for Evaluation of HIV-1 Therapeutics and Pathogenesis. Methods Mol Biol. 2016;1354:221-35. doi: 10.1007/978-1-4939-3046-3_15
Seay K, Khajoueinejad N, Zheng JH, Kiser P, Ochsenbauer C, Kappes JC, Herold B, Goldstein H. The vaginal acquisition and dissemination of HIV-1 infection in a novel transgenic mouse model is facilitated by coinfection with HSV-2 and is inhibited by microbicide treatment. J. Virology 2015;89:9559-9570. doi: 10.1128/JVI.01326-15.
Seay K, Church C, Zheng JH, Deneroff K, Ochsenbauer C, Kappes JC, Liu B, Jeng EK, Wong HC, Goldstein H. In vivo activation of human NK Cells by treatment with an Interleukin-15 superagonist potently inhibits acute in vivo HIV-1 infection in humanized mice. J. Virology 2015;89:6264-6274. doi: 10.1128/JVI.00563-15.
Costantini LM, Irvin SC, Kennedy SC, Guo F, Goldstein H, Herold BC, Snapp EL. Engineering and exploitation of a fluorescent HIV-1 gp120 for live cell CD4 binding assays. Virology. 2015 476:240-248. doi: 10.1016/j.virol.2014.12.019.
Nixon B, Fakioglu E, Stefanidou M, Wang Y, Dutta M, Goldstein H, Herold BC. Genital herpes simplex virus type 2 infection in humanized HIV-transgenic mice triggers HIV shedding and is associated with greater neurological disease. J Infect Dis. 2014;209:510-22. doi: 10.1093/infdis/jit472.
Seay K, Qi X, Zheng JH, Zhang C, Chen K, Dutta M, Deneroff K, Ochsenbauer C, Kappes JC, Littman DR, Goldstein H. Mice transgenic for CD4-specific human CD4, CCR5 and cyclin T1 expression: a new model for investigating HIV-1 transmission and treatment efficacy. PLoS ONE. 2013;8(5):e63537. doi: 10.1371/journal.pone.0063537.